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SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8.4
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Total Omega-3s♢
690 mg
†
EPA (Eicosapentaenoic Acid)
330 mg
†
DHA (Docosahexaenoic Acid)
220 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Strong relevance to back pain
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Read More
9
Eicosapentaenoic acid aids pain relief
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study directly assesses EPA's effects
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) could relieve chronic low-back and knee pain in adults. The study was carefully structured as a randomized, double-blind, placebo-controlled trial, which helps ensure that the findings are reliable and unbiased.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Read More
9
EPA may protect discs from degeneration
Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.
High relevance to treatment effectiveness
We aimed to explore how eicosapentaenoic acid (EPA), an omega-3 fatty acid, can impact intervertebral disc degeneration, which is a common cause of lower back pain. In the study, we used Sprague Dawley rats that had their lumbar discs punctured to induce degeneration. After the surgery, the rats were split into two groups: one received a daily diet enriched with EPA and docosahexaenoic acid (DHA), while the other group followed a standard diet.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
Read More
Most Useful Reviews
9.5
Pain relief achieved
After developing stomach ulcers from pain medications, I switched to Nordic Naturals and noticed a significant improvement. My knee swelling and pain disappeared shortly after starting them. I highly recommend this product as it works better than any other brands I've tried, plus it has no unpleasant aftertaste.
Read More
9.5
Reduced knee pain
Champion, I had a voice. Sitting caused pain in my knees, but after using it, I found it much easier. If it helps, like it. May God grant you Paradise.
Read More
0
Stomach issues
Unfortunately, this product did not suit my stomach, causing cramps and back pain, making it a waste of money for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Strong relevance to back pain
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Read More
9
Eicosapentaenoic acid aids pain relief
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study directly assesses EPA's effects
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) could relieve chronic low-back and knee pain in adults. The study was carefully structured as a randomized, double-blind, placebo-controlled trial, which helps ensure that the findings are reliable and unbiased.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Read More
9
EPA may protect discs from degeneration
Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.
High relevance to treatment effectiveness
We aimed to explore how eicosapentaenoic acid (EPA), an omega-3 fatty acid, can impact intervertebral disc degeneration, which is a common cause of lower back pain. In the study, we used Sprague Dawley rats that had their lumbar discs punctured to induce degeneration. After the surgery, the rats were split into two groups: one received a daily diet enriched with EPA and docosahexaenoic acid (DHA), while the other group followed a standard diet.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
After a month of the omega-3 supplementation, we noticed a significant drop in specific blood markers indicating inflammation. By the end of the two-month period, advanced imaging techniques and tissue analysis revealed that the rats on the omega-3 diet had maintained better hydration and displayed less damage to their intervertebral discs compared to the control group.
These findings suggest that incorporating eicosapentaenoic acid into the diet could reduce the inflammation linked to disc degeneration, potentially offering a protective effect against the progression of back pain. This research opens pathways to exploring omega-3s as a viable treatment option for people suffering from chronic back issues.
Read More
9
Omega-3s reduce disc degeneration
Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.
High relevance to back pain
We aimed to find out how docosahexaenoic acid (DHA), a key omega-3 fatty acid, could affect intervertebral disc (IVD) degeneration, a common cause of lower back pain. In our study, we used a group of 12 rats, all of whom underwent a procedure to induce disc degeneration.
After the injury, half of the rats were given a daily supplement of omega-3 fatty acids, while the other half received only a sugar solution as control. Over the course of the study, we measured various outcomes related to inflammation and disc health.
We observed that the omega-3 group showed a significant reduction in blood markers associated with inflammation. Additionally, the results indicated that those receiving DHA were less affected by disc dehydration, and the tissue damage due to the induced injury was noticeably less severe in this group.
Overall, this suggests that increasing our intake of omega-3 fatty acids, like DHA, may offer protective effects against the degeneration of intervertebral discs and could potentially ease back pain related to this condition.
After the injury, half of the rats were given a daily supplement of omega-3 fatty acids, while the other half received only a sugar solution as control. Over the course of the study, we measured various outcomes related to inflammation and disc health.
We observed that the omega-3 group showed a significant reduction in blood markers associated with inflammation. Additionally, the results indicated that those receiving DHA were less affected by disc dehydration, and the tissue damage due to the induced injury was noticeably less severe in this group.
Overall, this suggests that increasing our intake of omega-3 fatty acids, like DHA, may offer protective effects against the degeneration of intervertebral discs and could potentially ease back pain related to this condition.
Read More
9
Omega-3s reduce dysmenorrhea pain
Effect of Clupeonella grimmi (anchovy/kilka) fish oil on dysmenorrhoea.
Significant findings on pain relief
We conducted a clinical trial to assess whether omega-3 fatty acids, particularly docosahexaenoic acid (DHA), could alleviate back pain associated with dysmenorrhea in young women. Our study involved 36 participants aged 18 to 22, who were divided into two groups. One group received a daily dose of fish oil containing DHA while the other received a placebo over three months.
After the supplementation, we observed a notable reduction in pain levels, as measured by a visual analogue scale. The fish oil group reported a score of 20.9, significantly lower than the 61.8 from the placebo group, showcasing a clear advantage of the fish oil treatment. Moreover, participants experienced a marked reduction in both back and abdominal pain.
Those taking the fish oil also needed fewer rescue doses of ibuprofen, suggesting that DHA may play a beneficial role in managing pain symptoms. However, it’s important to note that while our findings indicate a reduction in pain, distinguishing the isolated effect of DHA from eicosapentaenoic acid (EPA) was not possible in this study, as both were present in the fish oil used.
Overall, we found that dietary supplementation with fish oil rich in omega-3s could be a promising approach for young women suffering from dysmenorrhea-related back pain, although further studies might be necessary to explore the specific contributions of each fatty acid.
After the supplementation, we observed a notable reduction in pain levels, as measured by a visual analogue scale. The fish oil group reported a score of 20.9, significantly lower than the 61.8 from the placebo group, showcasing a clear advantage of the fish oil treatment. Moreover, participants experienced a marked reduction in both back and abdominal pain.
Those taking the fish oil also needed fewer rescue doses of ibuprofen, suggesting that DHA may play a beneficial role in managing pain symptoms. However, it’s important to note that while our findings indicate a reduction in pain, distinguishing the isolated effect of DHA from eicosapentaenoic acid (EPA) was not possible in this study, as both were present in the fish oil used.
Overall, we found that dietary supplementation with fish oil rich in omega-3s could be a promising approach for young women suffering from dysmenorrhea-related back pain, although further studies might be necessary to explore the specific contributions of each fatty acid.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.4
9.5
Reduced knee pain
Champion, I had a voice. Sitting caused pain in my knees, but after using it, I found it much easier. If it helps, like it. May God grant you Paradise.
9.5
Less back pain
I really like these omega-3 supplements. I have more energy and less back pain after battling tendonitis. I've purchased a second bottle because they help without side effects.
9.5
Osteoporosis prevention
High-quality omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and relieve back pain during flare-ups. They fight inflammation and support joint health.
9.5
Pain relief achieved
After developing stomach ulcers from pain medications, I switched to Nordic Naturals and noticed a significant improvement. My knee swelling and pain disappeared shortly after starting them. I highly recommend this product as it works better than any other brands I've tried, plus it has no unpleasant aftertaste.
Read More
8.8
Joint pain relief
This product is excellent for skin, joint pain, and overall health. I noticed a significant improvement in my skin and a considerable reduction in joint pain, especially with Evening Primrose. I highly recommend it.
